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現在位置首頁>實驗試劑制品>抗體>抗體>Abcam ab1386 Mouse monoclonal [2D2] to Bax prediluted 6ml
Abcam ab1386 Mouse monoclonal [2D2] to Bax prediluted 6ml
Abcam ab1386 Mouse monoclonal [2D2] to Bax prediluted 6ml
  • Abcam ab1386 Mouse monoclonal [2D2] to Bax prediluted 6ml

Abcam ab1386 Mouse monoclonal [2D2] to Bax prediluted 6ml

產品報價:詢價

更新時間:2013/6/20 13:23:01

地:美國

牌:Abcam

號:ab1386

廠商性質: 生產型,貿易型,服務型,

公司名稱: 上海盈東生物科技有限公司

產品關鍵詞:

182
訪問人數
0
累計評論


錢先生 : (18621872635) (4000210588)

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Overview

Product name

Anti-Bax antibody [2D2], prediluted
參閱全部 Bax 抗體 (25) ...

Description

Mouse monoclonal [2D2] to Bax, prediluted

Specificity

This antibody recognizes a 211 kDa protein identified as bax protein. This antibody is highly specific to bax and does not cross react with bcl-2 alpha or bcl-X protein.

Tested applications

IHC-P, IHC-Frmore details

Cross reactivity

 

Reacts with

Human

Does not react with

Mouse, Rat

 

Immunogen

BALB/C mice were injected with a synthetic peptide amino acids 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein.

C-GSGEQPRGGGPTSS

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: Inert stabilizer

Concentration

 

  • 6 ml

 

Clonality

Monoclonal

Clone number

2D2

Isotype

IgG1

Research areas

Metabolism >> Pathways and Processes >> Metabolism processes >> Apoptosis
Cancer >> Invasion/microenvironment >> Apoptosis >> Bcl 2 family
Cell Biology >> Apoptosis >> Intracellular >> Associated Proteins
 

  • Datasheet PDF

Applications

Show applications key

Our Abpromise guarantee covers the use of ab1386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     
  • IHC-Fr

     

Application notes

This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections.
No further titration is required.
We suggest an incubation period of 30-60 minutes at room temperature.
However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user.
Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 1mM EDTA, pH 8.0 prior to immunostaining.

Target

Function

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Tissue specificity

Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.

Sequence similarities

Belongs to the Bcl-2 family.

Domain

Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.

Cellular localization

Cytoplasm and Mitochondrion membrane. Cytoplasm. Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.

Information by UniProt

Alternative names

  • apoptosis regulator BAX antibody
  • Apoptosis regulator BAX cytoplasmic isoform beta antibody
  • Apoptosis regulator BAX membrane isoform alpha antibody
see all

Database links

  • Entrez Gene: 581 Human
  • Omim: 600040 Human
  • SwissProt: Q07812 Human
  • Unigene: 624291 Human

 



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